Change of Intestinal Microbiome in Patients with Coronavirus Infection

The purpose of the study was to analyze modern literature on problems dysbiosis in patients with COVID-19, main mechanisms systemic interaction between intestine and lungs, as well changes microbiota that occur under influence coronavirus infection. Materials methods. A comprehensive selection research methods used for work: systematization material, method generalization, analysis synthesis. Scientific works field microbiology, epidemiology infectious diseases were studied. Literature data last 2 years (2019-2021) considered. results bacteriological studies from COVID infection described. obtained processed using information-analytical statistical-analytical Results discussion. As a result this work, complex connections which is called "intestinal-lung axis", It known these two biotopes occurs participation microflora its metabolites. Dysfunction intestinal barrier accompanied by bacterial translocation. Bacteria lumen enter liver through portal vein system. lymphatic pathway translocation lungs also possible, causes multiple organ failure syndrome COVID-19 virus able reduce number ACE2 receptors gastrointestinal tract, leads an imbalance intestines. At same time, process promotes growth bacteria Enterobacteriacae family intestine, dysbiotic disorders. use probiotics effective tool treatment infection, facilitates general condition patients. In course treatment, it important not only eliminate body, but restore normal after Conclusion. Thus, probiotic drugs can significantly risk developing improve perspective direction development new regimens conditions probiotics, eubiotics, synbiotics postbiotics prevent severe complications